医 学 部 教 师 基 本 情 况
姓名：李凤丽
性别：女
出生年月：1993.03
职务：无
职称：讲师
邮箱：13971267286@163.com
研究方向：微生物来源的天然产物的分离鉴定、生物活性及生物合成研究
教育经历（从本科学历开始）：
(1) 2012.09-2016.06 湖北中医药大学，药学院，药物制剂，学士
(2) 2016.09-2021.06 华中科技大学，药学院，药物化学，硕博连读，导师：张勇慧教授
工作经历：
(1) 2021.07-2025.01 华中科技大学，药学院，博士后（助理研究员），合作导师：张勇慧教授
(2) 2023.07-2023.09 德国马尔堡大学，药物生物学研究所，访问学习，合作导师：李书明教授
(3) 2025.02-至今 武汉科技大学，医学部药学系
代表性成果（项目、论文、著作等均可）：
1. 主持科研项目
(1) 国家自然科学青年基金，Aspergillus undulatus中靶向TNF-α抗银屑病活性的新颖二倍半萜的发现及作用机制研究，82404468，2025.01-2027.12，30万元，在研，主持
(2) 武汉科技大学人才引进项目，2025.01-2029.12，10万元，在研，主持。
(3) 湖北省博士后创新研究基金，Asperterpene A的全生物合成路径解析，6万元，主持，结题
2. 代表性论文
(1) Fengli Li, Suitian Lai, Wenlin Yuan, Zhe Chen, Zhenhua Guan, Chunmei Chen, Hucheng Zhu, Yuan Zhou, Jaclyn M. Winter, Zheng Xiang, Junjun Liu, Ying Ye, Yonghui, Zhang, Conformational Control in Diterpene Synthase TlnA: Elucidating the mechanism of 5−8−6 Skeleton Formation through Ring Expansion, Org. Lett. 2024, 26, 1734-1738. (自然指数期刊，Chemistry, Organic, 4/58, TOP10%)
(2) Fengli Li, Shuang Lin, Sitian Zhang, Xincai Hao, Xiao-Nian Li, Beiye Yang, Junjun Liu, Jianping Wang, Zhengxi Hu, Yonghui Zhang, Alterbrassinoids A-D: Fusicoccane-Derived Diterpenoid Dimers Featuring Different Carbon Skeletons from Alternaria brassicicola, Org. Lett. 2019, 21, 8353-8357. (自然指数期刊，Chemistry, Organic, 4/58, TOP10%)
(3) Fengli Li, Weiguang Sun, Jiankun Guan, Yuanyuan Lu, Sitian Zhang, Shuang Lin, Junjun Liu, Weixi Gao, Jianping Wang, Zhengxi Hu, Yonghui Zhang, Alterbrassicicene A, a Highly Transformed Fusicoccane-Derived Diterpenoid with Potent PPAR-γ Agonistic Activity from Alternaria brassicicola, Org. Lett. 2018, 20, 7982-7986. (自然指数期刊，Chemistry, Organic, 4/58, TOP10%)
(4) Zhengxi Hu, Weiguang Sun, Fengli Li (共同第一作者), Jiankun Guan, Yuanyuan Lu, Junjun Liu, Ying Tang, Guang Du, Yongbo Xue, Zengwei Luo, Jianping Wang, Hucheng Zhu, Yonghui Zhang, Fusicoccane-Derived Diterpenoids from Alternaria brassicicola: Investigation of the Structure-Stability Relationship and Discovery of an IKKβ Inhibitor, Org. Lett. 2018, 20, 5198-5202. (自然指数期刊，Chemistry, Organic, 4/58, TOP10%)
(5) Qin Li, Meijia Zheng, Fengli Li (共同第一作者),, Yongqi Li, Chunmei Chen, Zijian Huang, Junjun Liu, Weiguang Sun, Ying Ye, Hucheng Zhu, Yonghui Zhang, Talarolactones A-G, α-Pyrone Dimers with Anti-inflammatory Activities from Talaromyces adpressus, and Their Biosynthetic Pathways, Org. Lett. 2023, 25, 1616-1621. (自然指数期刊，Chemistry, Organic, 4/58, TOP10%，)
(6) Fengli Li, Shuyuan Mo, Jie Yin, Sitian Zhang, Saisai Gu, Zi Ye, Jianping Wang, Zhengxi Hu, Yonghui Zhang, Structurally diverse metabolites from a soil-derived fungus Aspergillus calidoustus, Bioorg. Chem. 2022, 127, 105988. (中科院一区，TOP期刊)
(7) Fengli Li, Zi Ye, Zhangyan Huang, Xia Chen, Weiguang Sun, Weixi Gao, Sitian Zhang, Fei Cao, Jianping Wang, Zhengxi Hu, Yonghui Zhang, New α-pyrone derivatives with herbicidal activity from the endophytic fungus Alternaria brassicicola, Bioorg. Chem. 2021, 117, 105452. (中科院一区，TOP期刊)
(8) Fengli Li, Shan Yan, Zhangyan Huang, Weixi Gao, Sitian Zhang, Shuyuan Mo, Shuang Lin, Jianping Wang, Zhengxi Hu, Yonghui Zhang, Inducing new bioactive metabolites production from coculture of Pestalotiopsis sp. and Penicillium bialowiezense. Bioorg. Chem. 2021, 110, 104826. (中科院一区，TOP期刊)
(9) Fengli Li, Lifen Pan, Shuang Lin, Sitian Zhang, Huaqiang Li, Beiye Yang, JunjunLiu, Jianping Wang, Zhengxi Hu, Yonghui Zhang, Fusicoccane-derived diterpenoids with bridgehead double-bond-containing tricyclo[9.2.1.03,7]tetradecane ring systems from Alternaria brassicicola, Bioorg. Chem. 2020, 100, 103887. (中科院一区，TOP期刊)
(10) Fengli Li, Ying Tang, Weiguang Sun, Jiankun Guan, Yuanyuan Lu, Sitian Zhang, Shuang Lin, Jianping Wang, Zhengxi Hu, Yonghui Zhang, New cytotoxic tricycloalternarenes from fungus Alternaria brassicicola, Bioorg. Chem. 2019, 92, 103279. (中科院一区，TOP期刊)
(11) Fengli Li, Weiguang Sun, Sitian Zhang, Weixi Gao, Shuang Lin, Beiye Yang, Chenwei Chai, Huaqiang Li, Jianping Wang, Zhengxi Hu, Yonghui Zhang, New cyclopiane diterpenes with anti-inflammatory activity from the sea sediment-derived fungus Penicillium sp. TJ403-2, Chin. Chem. Lett. 2020, 31, 197-201. (中科院一区，TOP期刊)
(12) Fengli Li, Shuang Lin, Sitian Zhang, Lifen Pan, Chenwei Chai, Jun- Cheng Su, Beiye Yang, Junjun Liu, Jianping Wang, Zhengxi Hu, Yonghui Zhang, Modified Fusicoccane-Type Diterpenoids from Alternaria brassicicola, J. Nat. Prod. 2020, 83, 1931-1938. (中科院一区，TOP期刊)
(13) Fengli Li, Weiguang Sun, Jiankun Guan, Yuanyuan Lu, Shuang Lin, Sitian Zhang, Weixi Gao, Junjun Liu, Guang Du, Jianping Wang, Hucheng Zhu, Changxi Qi, Zhengxi Hu, Yonghui Zhang, Anti-inflammatory fusicoccane-type diterpenoids from the phytopathogenic fungus Alternaria brassicicola, Org. Biomol. Chem. 2018, 16, 8751-8760.
(14) Fengli Li, Saisai Gu, Sitian Zhang, Shuyuan Mo, Jieru Guo, Zhengxi Hu, Yonghui Zhang, Three new amide derivatives from the fungus Alternaria brassicicola, Nat. Prod. Bioprospect 2023, 13, 28. (Q1)
(15) Fengli Li, Zhangyan Huang, Shuyuan Mo, Saisai Gu, Sitian Zhang, Beiye Yang, Jianping Wang, Zhengxi Hu, Yonghui Zhang, Two undescribed pairs of isoprenyl hydroxybenzoic acid derivatives from coculture of Pestalotiopsis sp. and Penicillium bialowiezense: enantioseparation and their absolute configurations, New J. Chem. 2022, 46, 17149-17152.
