医 学 部 教 师 基 本 情 况
姓名：林爽
性别：女
出生年月：1996年7月
职务：无
职称：讲师
邮箱：linshuang@wust.edu.cn; 13207186519@163.com
研究方向：
（1) 中药及天然药物药效物质基础的研究
（2) 特境真菌中新颖结构天然产物的发现及活性研究
教育经历（从本科学历开始）：
2013.9-2017.6 河南大学 药学院，药学 学士
2017.9-2022.6 华中科技大学 药学院，药物化学 博士，导师：张勇慧 教授
工作经历：
2022.7-2025.7 华中科技大学 药学院，药物化学 博士后（助理研究员）
2022.7-2022.8 德国马尔堡大学，访问学者
2025.7-至今 武汉科技大学 医学部 讲师（香涛学者青年百人）
代表性成果（项目、论文、著作等均可）：
一、主持科研项目
（1）国家自然基金青年科学基金，2024.01–2026.12，在研，主持。
（2）武汉科技大学人才引进项目，2025.08–2030.08，在研，主持。
二、发表论文：
(1) Lin, S.; Zhang, X.; Wang, H.; Qiao, Y.; Yu, J.; Peng, Y.; Wang, C.; Cao, F.; Yin, W. B.; Chen, C.; Zhu, H.; Zhou, Y.; Sun, W.*; Hu, Z.; Ye, Y.; Zhang, Y., Diasperonins A−F: Anti-inflammatory aspertetronin dimers discovered via bbmn and heterologous expression strategy. Org. Lett. 2025, 27, 5435−5439.
(2) Lin, S.; Huang, J.; Zeng, H.; Tong, Q.; Zhang, X.; Yang, B.; Ye, Y.; Wang, J.; Hu, Z.; Zhang, Y., Distachydrimanes A–F, phenylspirodrimane dimers and hybrids with cytotoxic activity from the coral-derived fungus Stachybotrys chartarum. Chinese Chemical Letters 2022, 33, 4587−4594.
(3) Lin, S.; Zeng, H.; Wang, C.; Chai, Z.; Zhang, X.; Yang, B.; Chi, J.; Zhang, Y.; Hu, Z., Discovery of novel natural cardiomyocyte protectants from a toxigenic fungus Stachybotrys chartarum. Bioorg. Chem. 2024, 148, 107461.
(4) Lin, S.; Yan, S.; Liu, Y.; Zhang, X.; Cao, F.; He, Y.; Li, F.; Liu, J.; Wang, J.; Hu, Z.; Zhang, Y., New secondary metabolites with immunosuppressive and BChE inhibitory activities from an endophytic fungus Daldinia sp. TJ403-LS1. Bioorg. Chem. 2021, 114, 105091.
(5) Lin, S.; Yu, H.; Yang, B.; Li, F.; Chen, X.; Li, H.; Zhang, S.; Wang, J.; Hu, Y.; Hu, Z.; Zhang, Y., Reisolation and configurational reinvestigation of cottoquinazolines E−G from an arthropod-derived strain of the fungus Neosartorya fischeri. J. Nat. Prod. 2020, 83, 169−173.
(6) Lin, S.; Chai, Z.; Zeng, H.; Yang, B.; Chi, J.; Zhang, Y; Hu, Z., Atranones and dolabellanes with cardiomyocyte protective activity against cold ischemic injury from a coral-associated fungus Stachybotrys chartarum. Phytochemistry 2024, 225, 114199.
(7) Lin, S.; He, Y.; Li, F.; Yang, B.; Liu, M.; Zhang, S.; Liu, J.; Li, H.; Qi, C.; Wang, J.; Hu, Z.; Zhang, Y., Structurally diverse and bioactive alkaloids from an insect-derived fungus Neosartorya fischeri. Phytochemistry 2020, 175, 112374.
(8) Lin, S.; Zhang, X.; Shen, L.; Mo, S.; Liu, J.; Wang, J.; Hu, Z.*; Zhang, Y.*, A new abietane-type diterpenoid and a new long-chain alkenone from fungus Daldinia sp. TJ403-LS1. Nat. Prod. Res. 2022, 36, 531−538.
(9) Li, F.; Lin, S.; Zhang, S.; Pan, L.; Chai, C.; Su, J. C.; Yang, B.; Liu, J.; Wang, J.; Hu, Z.; Zhang, Y., Modified fusicoccane-type diterpenoids from Alternaria brassicicola. J. Nat. Prod. 2020, 83, 1931−1938.
(10) Gu, X.; Zheng, M.; Gao, Y.; Lin, S.; Zhang, X.; Chen, C.; Zhu, H.; Sun, W.; Zhang, Y., Overview of host-directed antiviral targets for future research and drug development. Acta Pharm Sin B 2025, 15, 1723−1751.
(11) Zeng, H.; Wang, Y.; Wang, C.; Huang, Y.; Lin, S.; Wei, J.; Sun, W.; Cao, F.; Zhang, Y.; Hu, Z., Structurally diverse duclauxins from a coral-derived Talaromyces sp. and insight into determining the configuration at C-1 of heptacyclic duclauxins by 1H NMR. J. Nat. Prod. 2024, 87, 2592−2603.
(12) Yang, B.; Su, J.; Huang, L.; Lin, S.; Jin, X.; Lei, X.; Hu, Z.; Zhang, Y., Hyperispirones A and B, spiro-bridged polycyclic polyprenylated acylphloroglucinols with anti-angiogenesis activity from Hypericum beanii. Organic Chemistry Frontiers 2022, 9, 3460-3466.
(13) Yang, B.; Huang, J.; Lin, S.; Tong, Q.; Yao, Z.; Li, F.; Ye, Y.; Hu, Z.; Zhang, Y., Hyperbeanone A, a 5,6-seco-spirocyclic polycyclic polyprenylated acylphloroglucinol derivative with an unprecedented skeleton from Hypericum beanii. Organic Chemistry Frontiers 2021, 8, 6411−6418.
(14) Yang, B.; Qi, C.; Yao, Z.; Lin, S.; Li, F.; Sun, W.; Hu, Z.; Zhang, Y., Hybeanones A and B, Two Highly Modified Polycyclic Polyprenylated Acylphloroglucinols from Hypericum beanii. Chin. J. Chem. 2021, 40, 53−58.
(15) Li, F.; Lin, S.; Zhang, S.; Hao, X.; Li, X.; Yang, B.; Liu, J.; Wang, J.; Hu, Z.; Zhang, Y., Alterbrassinoids A–D: Fusicoccane-Derived Diterpenoid Dimers Featuring Different Carbon Skeletons from Alternaria brassicicola. Organic Letters 2019, 21, 8353−8357.
